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Symbol
Name
ID

Tlr4
toll-like receptor 4
MGI:96824

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Epistaxis	Neutrophilia	Leukocytosis	Arterial thrombosis	Superficial thrombophlebitis	Hyperfibrinogenemia	Abnormality of thrombocytes	Elevated erythrocyte sedimentation rate	Splenomegaly
Disease(s) Associated with TLR4	Epistaxis	Neutrophilia	Leukocytosis	Arterial thrombosis	Superficial thrombophlebitis	Hyperfibrinogenemia	Abnormality of thrombocytes	Elevated erythrocyte sedimentation rate	Splenomegaly
Behcet's disease
familial mediterranean fever
temporal arteritis

Mouse Phenotypes

hematopoietic system phenotype

decreased macrophage apoptosis

abnormal osteoclast differentiation

abnormal macrophage chemotaxis

impaired neutrophil chemotaxis

decreased B cell proliferation

increased spleen weight

decreased hemoglobin content

decreased memory B cell number

decreased B cell number

abnormal phagocyte morphology

abnormal spleen weight

abnormal T-helper 2 physiology

abnormal macrophage physiology

decreased macrophage cytokine production

abnormal microglial cell physiology

Availability

Mouse Genotype

Tlr4^lps-4Btlr/Tlr4^lps-4Btlr

Tlr4^lps-5Btlr/Tlr4^lps-5Btlr

Tlr4^Lps-6Btlr/Tlr4^Lps-6Btlr

Tlr4^lps-7Btlr/Tlr4^lps-7Btlr

Tlr4^Lps-8Btlr/Tlr4^Lps-8Btlr

Tlr4^lps-Btlr/Tlr4^lps-Btlr

Tlr4^Lps-d/Tlr4^Lps-d

*

Tlr4^lps-del/Tlr4^lps-del

Tlr4^lps-n/Tlr4^lps-n

Tlr4^tm1Aki/Tlr4^tm1Aki

Tlr4^lps-4Btlr/Tlr4⁺

Tlr4^Lps-6Btlr/Tlr4⁺

Tlr4^lps-7Btlr/Tlr4⁺

Tlr4^Lps-8Btlr/Tlr4⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23